PATIENT OR CAREGIVER
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Reconstituting VELETRI® (epoprostenol) for Injection

Thoroughly wash your hands with soap and warm water for at least one minute, then dry. To help prevent infection, clean your work surface with disinfectant wipes or 70% alcohol.

 

Remove the caps from the vial of VELETRI and from the normal saline (NS) or sterile water (SW).

If you are using the 0.5 mg vial of VELETRI, the cap will be white.

 

Clean the rubber stoppers of the vials of VELETRI and NS or SW with a disinfectant or antiseptic pad, or a pad with 70% alcohol.

Important: VELETRI is stable only when reconstituted as directed using Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. VELETRI must not be reconstituted or mixed with any other intravenous medications or solutions prior to or during administration. The same solution must be used for both reconstituting and diluting VELETRI. Do not combine sterile water with normal saline when preparing VELETRI.

These solutions are commercially available and can be purchased from either regular or specialty pharmacies.

Hold the 5-mL or 10-mL syringe with needle and draw back the plunger to the 5-mL mark to draw in air.

Be careful to avoid touching the plunger shaft.

Confirm that the needle is tightly attached to the syringe before removing the needle cap.

 

Insert the needle's tip bevel up (see inset) into the NS or SW vial at a 45-degree angle. Push the needle into the core of the vial. Press down on the plunger to inject the air from the syringe into the solution.

 

With the needle still inserted into the vial, turn the vial upside down.

Position the needle tip below the fluid level, and draw the prescribed amount of NS or SW into the syringe.

 

Gently pull the syringe out of the vial.

 

To add the prescribed amount of NS or SW to the powdered VELETRI medication vial, insert the needle's tip bevel up (see inset) at a 45-degree angle into the rubber stopper.

 

Slowly inject the NS or SW, making sure to prevent turbulence and foaming of the medication.

 

DO NOT SHAKE. Gently roll the vial of VELETRI in your hands until the powder is completely dissolved and the solution is clear.

Turn the vial upside down to trap any undissolved powder that may be present near the top of the vial. Cloudiness and particles should not be present in the solution.

 

Draw back the appropriate amount of medication from the vial into the 5-mL or 10-mL syringe based on the desired concentration.

Recap the syringe and put it down on your clean work surface. You are now ready to fill the medication cassette.

Note: Please advise your patients to be cautious when re-capping the needle. There are alternatives to re-capping the needle, so please discuss this step with your patients.

Repeat steps 2 through 11 if more than one vial of VELETRI is being used.

Note: The same solution must be used for both reconstituting and diluting VELETRI. Do not combine sterile water with normal saline when preparing VELETRI.