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Storage and Administration Options for VELETRI® (epoprostenol) for Injection

Follow all instructions to ensure that VELETRI retains its stability and that the proper dosage is delivered.

Storage options

8-day storage and once-weekly preparation

  • Prepare VELETRI for immediate use, OR prepare up to 8 fully diluted cassettes once weekly and refrigerate (36° to 46°F/2° to 8°C) for up to 8 days, for use at room temperature.

24-hour room temperature stability at all concentrations

  • Administer VELETRI for up to 24 hours at room temperature (77°F/25°C) at any concentration without ice packs.
  • Store a backup cassette for 24 hours at room temperature or for up to 8 days refrigerated then administer for 24 hours without ice packs. Do not expose VELETRI to direct sunlight.
  • Note: It is recommended that a single cassette not be administered by pump beyond 24 hours.

Short excursions at 104°F/40°C are permitted for up to:

  • 2 hours for concentrations below 15,000 ng/mL.
  • 4 hours for concentrations between 15,000 ng/mL and 60,000 ng/mL.
  • 8 hours for concentrations above 60,000 ng/mL.
  • Patients may administer VELETRI without ice packs and remain on the same 24-hour cassette.
  • Note: It is recommended that a single cassette not be administered by pump beyond 24 hours.

Note: It is recommended that a single cassette not be administered by pump beyond 24 hours.

The 0.5 mg vial is to be used for patients on concentrations of VELETRI <15,000 ng/mL.

Reconstitute VELETRI only as directed using Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. Do not mix VELETRI with any other parenteral medications or solutions prior to or during administration. Each vial is for single use only; discard any unused solution. Use after reconstitution and immediate dilution to final concentration. Use at room temperature (77°F/25°C). Do not expose VELETRI to direct sunlight.

VELETRI should be used only by clinicians experienced in the diagnosis and treatment of pulmonary hypertension.

Review the Patient Counseling Information with patients when initiating therapy.

Dilution1

  • Reconstituted product should be further diluted as directed with the same diluent used for reconstitution. The diluted solution may be used for up to 24 hours at room temperature at any concentration. For concentrations below 60,000 ng/mL, it is recommended that a single cassette not be administered by pump beyond 24 hours.
  • Solution for chronic delivery should be prepared in a drug delivery reservoir appropriate for the infusion pump.
  • Stability depends on concentration, temperature, and timing of dilution and administration. Do not expose VELETRI to direct sunlight.

For more information about storing VELETRI, please see the full Prescribing Information.